Descriptive Statistics

Population in the catchment area and EAGLE subjects
by area of residence, gender, and age (matching variables)

Area	Population		Cases		Controls
	No.	%	No.	%	No.	%
Brescia	272,786	16.6	275	13.1	248	11.7
Milan	963,341	58.7	1369	65.2	1440	67.9
Monza	155,491	9.5	144	6.8	117	5.5
Pavia	122,036	7.4	137	6.5	130	6.1
Varese	128,420	7.8	176	8.4	185	8.7
Total	1,642,074	100.0	2101	100.0	2120	100.0
Gender	No.	%	No.	%	No.	%
Females	867,310	52.8	449	21.4	500	23.6
Males	774,764	47.2	1652	78.6	1620	76.4
Total	1,642,074	100.0	2101	100.0	2120	100.0
Age	No.	%	No.	%	No.	%
35-39	242,876	14.8	12	0.6	17	0.8
40-44	203,923	12.4	19	0.9	28	1.3
45-49	185,568	11.3	52	2.5	71	3.3
50-54	206,127	12.6	133	6.3	127	6.0
55-59	183,214	11.2	240	11.4	300	14.1
60-64	196,734	12.0	359	17.1	371	17.5
65-69	167,764	10.2	474	22.6	489	23.1
70-74	143,191	8.7	471	22.4	424	20.0
75-79	112,677	6.9	341	16.2	293	13.8
Total	1,642,074	100.0	2101	100.0	2120	100.0

 

EAGLE lung cancer cases by histology and cigarette smoking status

Histology	Never smokers		Former smokers		Current smokers		Missing		Total
Females	No.	%	No.	%	No.	%	No.	%	No.	%
Non small cell carcinoma (NSCLC)	101	87.8	96	78.0	147	73.1	9	90.0	353	78.6
Adenocarcinoma	85	73.9	64	52.0	91	45.3	4	40.0	244	54.3
Squamous cell	7	6.1	19	15.4	22	11.0	1	10.0	49	10.9
Large cell	2	1.7	6	4.9	12	6.0	0	0.0	20	4.5
NSCLC, not defined	7	6.1	7	5.7	22	11.0	4	40.0	40	8.9
Small cell carcinoma	3	2.6	8	6.5	29	14.4	0	0.0	40	8.9
Others (mixed types)	5	4.4	13	10.6	18	9.0	1	10.0	37	8.2
Missing	6	5.2	6	4.9	7	3.5	0	0.0	19	4.2
Total	115	100.0	123	100.0	201	100.0	10	100.0	449	100.0
Males	No.	%	No.	%	No.	%	No.	%	No.	%
Non small cell carcinoma (NSCLC)	28	84.9	607	80.1	663	78.8	13	65.0	1311	79.4
Adenocarcinoma	20	60.6	283	37.3	305	36.3	6	30.0	614	37.2
Squamous cell	5	15.2	233	30.7	241	28.7	5	25.0	484	29.3
Large cell	0	0.0	23	3.0	34	4.0	0	0.0	57	3.5
NSCLC, not defined	3	9.1	68	9.0	83	9.9	2	10.0	156	9.4
Small cell carcinoma	1	3.0	73	9.6	100	11.9	2	10.0	176	10.7
Others (mixed types)	1	3.0	39	5.2	39	4.6	1	5.0	80	4.8
Missing	3	9.1	39	5.2	39	4.6	4	20.0	85	5.1
Total	33	100.0	758	100.0	841	100.0	20	100.0	1652	100.0

 

EAGLE lung cancer cases by stage and cigarette smoking status

Stage	Never smokers		Former smokers		Current smokers		Missing		Total
Females	No.	%	No.	%	No.	%	No.	%	No.	%
0	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0
IA	11	9.6	13	10.6	20	10.0	2	20.0	46	10.2
IB	14	12.2	13	10.6	23	11.4	0	0.0	50	11.1
IIA	0	0.0	3	2.4	4	2.0	0	0.0	7	1.6
IIB	10	8.7	10	8.1	14	7.0	0	0.0	34	7.6
IIIA	13	11.3	18	14.6	26	12.9	0	0.0	57	12.7
IIIB	18	15.6	15	12.2	28	13.9	3	30.0	64	14.3
IV	48	41.7	50	40.7	81	40.3	5	50.0	184	41.0
X	1	0.9	1	0.8	5	2.5	0	0.0	7	1.6
Total	115	100.0	123	100.0	201	100.0	10	100.0	449	100.0
Males	No.	%	No.	%	No.	%	No.	%	No.	%
0	0	0.0	1	0.1	0	0.0	0	0.0	1	0.1
IA	3	9.1	78	10.3	59	7.0	1	5.0	141	8.5
IB	1	3.0	109	14.4	94	11.2	1	5.0	205	12.4
IIA	0	0.0	11	1.4	11	1.3	0	0.0	22	1.3
IIB	4	12.1	65	8.6	76	9.0	1	5.0	146	8.8
IIIA	1	3.0	78	10.3	97	11.5	1	5.0	177	10.7
IIIB	4	12.1	102	13.5	150	17.8	3	15.0	259	15.7
IV	20	60.6	295	38.9	333	39.6	12	60.0	660	40.0
X	0	0.0	19	2.5	21	2.5	1	5.0	41	2.5
Total	33	100.0	758	100.0	841	100.0	20	100.0	1652	100.0

 

EAGLE subjects by cigarette smoking status

Females	Cases		Controls
	No.	%	No.	%
Never smokers	115	25.6	282	56.4
Former smokers	123	27.4	110	22.0
Current smokers	201	44.8	107	21.4
Missing	10	2.2	1	0.2
Total	449	100.0	500	100.0
Males	No.	%	No.	%
Never smokers	33	2.0	397	24.5
Former smokers	758	45.9	799	49.3
Current smokers	841	50.9	420	25.9
Missing	20	1.2	4	0.3
Total	1652	100.0	1620	100.0

 

EAGLE subjects by cigarette pack-years
(former/current smokers)

Pack-years	Cases		Controls
Females	No.	%	No.	%
<10	32	10.5	97	44.7
10-19	56	18.4	50	23.0
20-29	65	21.4	32	14.8
30-39	59	19.4	17	7.8
40-49	40	13.2	11	5.1
50-59	22	7.2	5	2.3
60+	30	9.9	5	2.3
Total	304	100.0	217	100.0
Males	No.	%	No.	%
<10	37	2.5	264	21.7
10-19	81	5.4	199	16.4
20-29	155	10.3	226	18.6
30-39	265	17.6	187	15.4
40-49	296	19.7	154	12.7
50-59	233	15.5	83	6.8
60+	439	29.2	104	8.6
Total	1506	100.0	1217	100.0